Zacharias was born in Albania. Her parents immigrated to the United States and she grew up in New York on the west side of Manhattan in Hell’s Kitchen. She attended Queen’s College from 1952 to 1956 where she studied under art historian Robert Goldwater as well as John Ferren and Barse Miller. She then went to the University of California, Berkeley, where she met Mark di Suvero and studied with George McNeil and Erle Loran, receiving her M.F.A in 1957.
Returning to New York, Zacharias exhibited at the legendary March Gallery in the early 1960s along side di Suvero and received recognition and mention form Dore Ashton. Between 1960 to 1968, she lived and painted in an old sea captain’s residence at Coentis Slip near South Ferry in the same area as some of the most renowned figures in the art scene of that time: Jasper Johns, Robert Rauschenberg, Barnett Newman, Ellsworth Kelly, Mark di Suvero, Agnes Martin, James Rosenquist and Robert Indiana.
In the mid-60s, Zacharias exhibited at the Great Jones Gallery along with Louise Bourgeois and in the early 1970s, at Green Mountain Gallery in Soho in Lower Manhattan. In the mid-1970s, Zacharias became somewhat reclusive and avoided exhibiting in galleries. However, she continued to paint everyday in her studio and evolve her own visual language and experimental methods of application on new and novel supports. Also, from the 1980s through 2000, she was closely associated with Socrates Sculpture Park in Long Island City, Queens and working with local children groups and teaching. She worked on two large commissions for the Park, including a brightly colored 35-foot mural. In 2006, Zacharias contributed a work to the "Peace Tower" shown at the Whitney biennial of that same year. She continues to paint, albeit on a much smaller scale.